A polynucleotide treatment known for its firming effect as well as its regenerative action, with dedicated formulations for the face, neck and eye area.
Nucleofill is a polynucleotide treatment used to improve skin quality while also supporting a noticeable firming and tightening effect. Dr Ellie Sateei offers Nucleofill at her London and Sevenoaks clinics for patients wanting regeneration alongside a modest lift in skin tone.
It is often chosen where laxity is part of the concern, rather than skin quality alone.
Nucleofill is an injectable treatment containing purified polynucleotides in a gel of higher density than some other products in the category. This gives it a mild volumising and tightening quality alongside the regenerative signalling that defines polynucleotide treatment.
The range includes formulations designed for the face, the neck and décolletage, and the delicate eye area, each prepared at a concentration and density suited to that tissue.
Nucleofill is commonly used for mild skin laxity, crepey texture, fine lines and dehydration across the face, neck and décolletage. The eye formulations are used for thin, crepey under-eye skin and the dark shadowing that can come with it.
Dr Sateei will assess your skin and the degree of laxity present during consultation to determine whether Nucleofill’s firming character suits your goals, or whether a different polynucleotide would be a better match.
Treatment is delivered through a series of fine injections placed across the treatment area. Topical numbing can be used to improve comfort, and most patients describe mild discomfort.
Small raised points are visible immediately and typically settle within a few hours. Some mild swelling or bruising is common for a day or two. A course of sessions, usually spaced two to four weeks apart, is recommended, with firmness and skin quality building over this period.
Dr Sateei will be clear with you about what polynucleotide treatment can and cannot achieve, particularly where laxity is significant enough that another approach would serve you better. Her more than twenty years in dermatology and aesthetics inform that judgement.
Every course is tailored to your specific concerns following a thorough consultation, at both her London clinic near Harley Street and her Sevenoaks clinic in Kent.
Nucleofill is an injectable polynucleotide treatment that supports skin regeneration while also providing a mild firming effect.
Its higher gel density gives it a more noticeable tightening quality alongside the regenerative signalling common to the category.
Common concerns include mild skin laxity, crepey texture, fine lines and dehydration on the face, neck and décolletage.
Most patients describe mild discomfort, and topical numbing can be used to improve comfort.
Small raised points are visible immediately and settle within a few hours, with mild swelling or bruising possible for a day or two.
A course of sessions, usually spaced two to four weeks apart, is recommended for the fullest result.
Firmness and skin quality build gradually across the course of treatment.
Yes, dedicated formulations exist for the neck and décolletage as well as the face and eye area.
Most adults with mild laxity or reduced skin quality are suitable candidates, confirmed following a skin assessment.
No, it offers a modest firming effect rather than a lift, and Dr Sateei will advise if another approach would suit you better.
Nucleofill is one of several polynucleotide brands Dr Ellie Sateei uses, alongside Plinest and Rejuran, each of which has its own page. Plinest is lighter and purely regenerative, while Rejuran is more focused on the skin barrier.
The full list of other polynucleotide brands used across the clinic is on the polynucleotides (PDRN) page.
Brands named above that have their own page, for linking: Polynucleotides (PDRN) (/brands/polynucleotides), Plinest (/brands/plinest), Rejuran (/brands/rejuran)
Nucleofill firms as well as regenerates, so it suits skin that has softened rather than simply dulled. These are the concerns Dr Ellie Sateei treats with it most often.
If you would like to improve skin quality and firmness with a regenerative treatment, Dr Ellie Sateei welcomes a personal consultation at her London or Sevenoaks clinic.
Our London clinic is located at 91a New Cavendish Street, London, W1W 6XF
We serve patients from London, Kent and the home counties as well as from all over the world. Our London clinic sits in the heart of Marylebone, within easy reach of the West End by tube, while our Sevenoaks clinic in Ightham is moments from the M25 and M26 for patients across Kent.
